Global Protein Expression Market (Size of USD 2.85 billion in 2023) to Witness 12.8% CAGR during 2025–2030

Published Date: Feb, 2024

The global protein expression market was registered at USD 2.85 billion in 2023 and is estimated to reach USD 5.86 billion by 2030. The market is led by the increasing funds from government and non-government organization for protein research, the soaring prevalence of chronic diseases, rising life science industry. The use of microfluidic devices in profiling protein expression provides an opportunity for the growth of the market. The protein expression market is projected to grow at a CAGR of 12.8% during the forecast period (2025-2030).

Asia-Pacific protein expression industry is expected to witness considerable growth at a high CAGR of 12.8% during the forecast period. The growth is driven by the increasing life science funding, rise in the number of chronic diseases in the region. Also, the emerging economies of the region provide immense opportunities for key players to explore the untapped market.

On the basis of products and services offered in the protein expression market, the reagents held the largest share in the global market, in 2020. The large volume of reagents utilized in research activities and the large scale production of antibodies and vaccines has led to the high demand of reagents over another product category. These include expression vectors, competent cells, instruments, and services used in protein expression.

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The market is segmented into prokaryotic expression systems; yeast expression systems; mammalian cell expression systems; insect cell expression systems; cell-free expression systems; and algal-based expression systems, on the basis of systems. Among the available system types, the prokaryotic expression system registered to be the largest contributor, with 40.2% to the global market in 2019, due to the systems less cost over others.

Global Protein Expression Market Segmentation and Key Players

Segment / Key Players


Product & Services

Expression Vectors, Competent Cells, Reagents, Instruments, Services


Prokaryotic Expression Systems, Yeast Expression Systems, Mammalian Cell Expression Systems, Algal-Based Expression Systems Insect Cell Expression Systems, Cell-Free Expression Systems


Therapeutics, Research, Industrial


Academic Research Institutes, Contract Research Organizations, Pharmaceutical And Biotechnology Companies, Others

Key Players

New England Biolabs, Inc., Thermo Fisher Scientific Inc., QIAGEN N.V., Takara Bio Inc., Lonza Group Ltd., Merck KGaA, Promega Corporation, Genscript Biotech Corporation, Agilent Technologies Inc., and Bio-Rad Laboratories, Inc.

Protein expression products and services are used in therapeutics, research, and industrial applications. The market is led by the high demand for products and services for therapeutics, due to the increasing prevalence of chronic diseases. On the basis of end user, the protein expression market is segmented into academic research institutes; contract research organizations; pharmaceutical and biotechnology companies; and others. The growth of the market in contract research organizations is expected to be the highest at a CAGR of 12.8% during the forecast period.

The market has witnessed the launch of product and services by manufacturers to increase their market share, for instance in June 2017, GenScript launched MonoRab, its new custom rabbit monoclonal antibody (mAb) service. The MonoRab technology uses hybridoma and early-stage monoclonal antibody sequencing for delivering custom rabbit mAbs with high specificity and affinity to address a range of applications. Some of the key players of the protein expression industry include New England Biolabs, Inc., Thermo Fisher Scientific Inc., QIAGEN N.V., Takara Bio Inc., Lonza Group Ltd., Merck KGaA, Promega Corporation, Genscript Biotech Corporation, Agilent Technologies Inc., and Bio-Rad Laboratories, Inc. 

Global Protein Expression Market Coverage

Product & Services Insight and Forecast 2025-2030

  • Expression vectors
  • Reagents
  • Competent cells
  • Instruments
  • Services

Systems Insight and Forecast 2025-2030

  • Prokaryotic expression systems
    • E. coli systems
    • Others
  • Yeast expression systems
    • Saccharomyces systems
    • K. Lactis systems
    • Pichia systems
    • Others
  • Mammalian cell expression systems
    • Chinese hamster ovary system
    • Others
  • Cell-free expression systems
  • Algal-based expression systems
  • Insect cell expression systems
    • Baculovirus systems
    • Others

Application Insight and Forecast 2025-2030

  • Therapeutics
  • Research
  • Industrial

End User Insight and Forecast 2025-2030

  • Academic research institutes
  • Contract research organizations
  • Pharmaceutical and biotechnology companies
  • Others

Geographical Segmentation

Protein Expression Market by Region

North America

  • U.S.
  • Canada


  • Germany
  • France
  • U.K.
  • Italy
  • Spain
  • Rest of Europe


  • China
  • Japan
  • India
  • Rest of Asia-Pacific

Rest of the World (RoW)

  • Brazil
  • Mexico
  • South Africa
  • Other countries 

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