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The U.S. protein expression market is set to reach USD 3.2 billion by 2030, growing at a CAGR of 11.8% during the forecast period. The increasing funding for recombinant protein expression from government and non-government organizations, advancement in technology for expression systems, growth in the life sciences industry, increasing prevalence of chronic diseases, and an aging population are the primary growth drivers for the U.S. protein expression market.

The geriatric population is prone to several chronic diseases which creates pressure among healthcare providers and other stakeholders to develop new efficient therapeutics with value-based outcome. In July 2015, 47.8 million people were aged 65 or above in the U.S., representing 14.9% of its total population. Also, the population of people aged 65 and older in the U.S. is projected to reach 98.2 million in 2060.

Lifesciences and biopharmaceutical companies are investing in research and development of biologics. With the high adverse effects and toxicity of the drug interaction for small molecule drugs, the demand for biologics is anticipated to increase. Biologics are more effective and have fewer side effects, thus, illustrating the high demand for protein expression systems in the coming years.

U.S. Protein Expression Market Segmentation and Key Players

Browse Market Insight and In-depth TOC on "U.S. Protein Expression Market – Analysis and Forecast (2025-2030)"

Different products and services in the protein expression industry include expression vectors, competent cells, reagents, instruments and services. Reagents hold the largest share in the U.S. market, as these are the key component for the successful protein expression. With the increasing number of research and development activities for protein biologics in life sciences industry; the demand for reagents is anticipated to increase significantly.

Based on systems, the market is segmented into prokaryotic expression systems, yeast expression systems, cell-free expression systems, mammalian cell expression systems, algal-based expression systems, and insect cell expression systems. Among the various systems being used in the market, the prokaryotic expression system hold the largest share in the U.S. protein expression market. Prokaryotic expression systems are further categorized into Escherichia coli systems, and other prokaryotic expression systems. The largest share of prokaryotic expression system is due to the cost effectiveness, as it is less expensive over other available categories; and the various applications of E.coli systems in research and industrial applications.

Yeast expression system market is further categorized into saccharomyces systems, K. lactis systems, Pichia systems and others. Among different types of mammalian cell expression systems, Chinese hamster ovary systems are most commonly used expression system. Similarly, among insect cell expression systems, baculovirus systems witness the largest demand in the market.

Among different applications including therapeutics, research, and industries, therapeutics contribute the largest revenue in the U.S. protein expression industry. The increasing number of chronic diseases on a global level led to the application of protein expression majorly in finding therapy for chronic diseases.

Academic research institutes, contract research organizations, and pharmaceutical and biotechnology companies are the major end users in the U.S. market. Pharmaceutical and biotechnology companies are the largest end user in the U.S. protein expression market. This is primarily due to the large production of recombinant proteins for therapeutics, and the growing advancement in technology with respect to protein research. The highest demand for protein expression products and services is anticipated from CROs during the forecast period.

Some of the players operating in the U.S. Protein Expression industry are New England Biolabs, Inc., Thermo Fisher Scientific Inc., QIAGEN N.V., Takara Bio Inc., Lonza Group Ltd., Merck KGaA, Promega Corporation, Genscript Biotech Corporation, Agilent Technologies Inc., and Bio-Rad Laboratories, Inc.

U.S. Protein Expression Market Coverage

Product & Services Insight and Forecast 2025-2030

• Expression vectors
• Reagents
• Competent cells
• Instruments
• Services

Systems Channel Insight and Forecast 2025-2030

• Prokaryotic expression systems
  • E. coli systems
  • Others
• Yeast expression systems
  • Saccharomyces systems
  • K. Lactis systems
  • Pichia systems
  • Others
• Mammalian cell expression systems
  • Chinese hamster ovary system
  • Others
• Cell-free expression systems
• Algal-based expression systems
• Insect cell expression systems
  • Baculovirus system
  • Others

Application Insight and Forecast 2025-2030

• Therapeutics
• Research
• Industrial

End-User Insight and Forecast 2025-2030

• Academic research institutes
• Contract research organizations
• Pharmaceutical and biotechnology companies
• Others